31-year-old Kieran Davey Rice, 29-year-old Urbino Vieira Rodrigues and 37-year-old Adam Hole have been remanded in custody until their next court appearance.
Mr Rice, who is defended by Advocate James Bell, is facing 10 counts of drug-trafficking offences, including possession and intent to supply. The drugs in question have an estimated total value of between £415,000 and £950,000 including cannabis, buprenorphine, cocaine and N-Ethlypentylone.
Mr Rodrigues, defended by Advocate Julian Gollop, has been charged with three counts of possession and intent to supply, involving the Class B drug N-Ethylpentylone.
Mr Hole, who is defended by Advocate Sue Pearmain, is facing a charge of importation of controlled drugs.