Binfield are bottom of the Isthmian South Central league on four points, with GFC sitting one place above them on six points and one point outside of the safety zone.
Last season, the Green Lions won both of their games against the Moles, 3-1 away and less than a fortnight later, 2-1 at Footes Lane.
Binfield confirmed earlier this week that Garry Haylock has left his role as first team manager.
“The club would like to pass on our thanks to Garry for his hard work and dedication whilst in the role and we wish him all the very best for the future.
“Binfield Football Club is now very much focused on turning our season around as we move into the busy Christmas and New Year period. We will be announcing the details of the new management team prior to our game against Guernsey this coming Saturday.”
The game kicks off at 13:00 at the Iconic Stadium.