The announcement by the company – signalled in a statement back in June – follows a review and restructure of their Jersey and UK operations.
Feelunique, Europe’s largest online beauty retailer, was founded in Jersey in 2005.
The company say some of the 50 staff whose jobs are being cut will be given alternative roles in the company.
In a statement, CEO Joel Palix said: “This has been an extremely difficult decision to take, but in order to compete on an international level, we know that this move is in the long term interests for feelunique.
“As a business we have sought to minimise redundancies as far as possible and have worked hard to find alternative employment for colleagues affected by this decision elsewhere within the organisation.”
Feelunique say that the decision will not affect their online team or their stores, salons and spa in Jersey.
The company was reported to have seen sales growth of 20% in 2014.
They offer 20,000 products and 500 brands.
The founders – Aaron Chatterley and Richard Schiessl – sold a majority stake in the business to private equity firm Palamon Capital Partners in a December 2012 deal which valued the business at £26 million.